MENU
|
| FNCA 2003 Workshop on Radiation Oncology |
FNCA 2003 Workshop on Radiation Oncology
|
| |
The FNCA 2003 Workshop on Radiation Oncology was held from December 15
to 18, 2003, in Suzhou (Soochow) and Shanghai, P.R. China. The meeting
was jointly organized by the Ministry of Education, Culture, Sports, Science
and Technology (MEXT) of Japan and the College of Nuclear Medicine, Soochow
University, in cooperation with the Japan Atomic Industrial Forum, Inc.
(JAIF) and Fudan University. Representatives from 8 FNCA countries, China,
Indonesia, Japan, Republic of Korea, Malaysia, the Philippines, Thailand
and Vietnam, participated in the workshop.
On the first day (Dec.15), at the Session 1 ("Follow-Up Status of
CERVIX-I"), the follow-up data of the CERVIX-I on 210 patients were
reported. According to the report, as of December 2003, the overall 5-year
survival rate was 53%, comparable to world wide and Japanese data, concluding
this protocol was feasible in FNCA countries based on the favorable outcome.
At the Session 2 ("Accelerated Hyperfractionation Radiotherapy :CERVIX-II)",
the follow-up data of CERVIX-II study as of December 2003 on 103 patients
was presented.
At the Session3 ("Chemoradiotherapy for Uterine Cervix Cancer"),
the Phase I study of concurrent chemoradiotherapy (CCRT) of uterine cervix
cancer was completed. A proposal of the Phase II Protocol of CCRT for Advanced
Uterine Cervix Cancer was distributed, discussed, and agreed upon. A hundred
patients are to be enrolled with a minimum of 12 per country. The protocol
was adopted as CERVIX-III.
On the second day (Dec.16), at the Session4 ("Pilot study of Chemoradiotherapy
for Nasopharyngeal Cancer"), the results of major randomized studies
and a meta-analysis, the results of the pilot study and a protocol for
a Phase I/II study were presented and discussed.
On the third day (Dec.17), at the Session5 ("QA/QC of Radiation Dosimetry"),
the results of fieldwork for physical QA/QC of brachytherapy were presented
with description of measurement technique. And at the Session 6 ("Future
plans and other relevant activities"), future plans were discussed
and approved.
On the day, as a technical tour, the participants visited Department of
Radiotherapy, Suzhou No.1 Hospital and Shanghai Zhong Shan Cancer Centre,
Fudan University.
The last day (Dec.18), the Open Lecture held at the Shanghai Zhong Shan
Cancer Centre, Fudan University, Shanghai City, China, as a part of the
workshop. Nine lectures were given by FNCA participants and two local Chinese
doctors. |
|
|
 |
|
 |
Participants of the FNCA 2003
Workshop on Radiation Oncology |
|
Workshop on Radiation Oncology |
|
| |
 |
Technical tour
(Liniac at the Suzhou No.1 Hospital) |
|
| |
- Program of FNCA 2003 Workshop-
on Radiation Oncology |
| |
| Opening Session |
|
|
| |
SESSION 1:
"Follow-Up Status of Patients Treated with the Standardized Protocol
of Radiation Therapy for Uterine Cervix Cancer (CERVIX-I)" |
|
|
| |
SESSION 2:
"Accelerated Hyperfractionation Radiotherapy for Uterine Cervix Cancer
(CERVIX-II)" |
|
|
| |
SESSION 3:
"Chemoradiotherapy for Uterine Cervix Cancer(CERVIX-III)" |
|
|
| |
SESSION 4:
"Pilot study of Chemoradiotherapy for Nasopharyngeal Cancer" |
|
|
| |
SESSION 5:
"QA/QC OF RADIATION DOSEMETRY" |
| Report of the Fieldwork |
| QA/QC Manuals |
| Schedule of the next Fieldwork |
|
| |
SESSION 6:
"Future plan, Other activities" |
|
|
| |
SESSION 7:
"Drafting the Workshop Minutes" |
| Adoption of the Minutes |
| Closing Remarks |
|
| Open Lecture |
|
|
| |
|
Minutes of the FNCA 2003 Workshop
on Radiation Oncology
December 15 to 18, 2003
Aster Hotel, Suzhou (Soochow),
and Fudan University, Shanghai, China
|
| | | | 1) | Following the agreement of the 4th Forum for Nuclear Cooperation in Asia (FNCA) Coordinators Meeting in March 2003, and the 4th FNCA Meeting in December 2003, the FNCA 2003 Workshop on Radiation Oncology was held from December 15 to 18, 2003, in Suzhou (Soochow) and Shanghai, P.R. China. The meeting was jointly organized by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan and the College of Nuclear Medicine, Soochow University, in cooperation with the Japan Atomic Industrial Forum, Inc. (JAIF) and Fudan University. Representatives from 8 FNCA countries, China, Indonesia, Japan, Republic of Korea, Malaysia, the Philippines, Thailand and Vietnam, participated in the workshop. | | | | | | Opening ceremony | | | 2) | Dr. Cao Jianping, Soochow University, acted as the moderator. The welcome remarks were delivered by Dr. Jianyi Ge, Soochow University, followed by remarks of Prof. Tong Jian, Soochow University. Ms. Tokuko Kuroyanagi, MEXT, made a speech of welcome and appreciation on behalf of Mr. Sakata, MEXT. Welcome remarks were also given by Mr. Li Xiang, China Atomic Energy Authority (CAEA) and finally by Dr. Hirohiko Tsujii, National Institute of Radiological Sciences (NIRS). (See Attachment) | |
| |
| | | | Session 1:
Follow-Up Status of CERVIX-I | | | 3) | The follow-up data of the CERVIX-I on 210 patients revealed that the study had only a small number of major late complications which is considered acceptable. As of December 2003, the overall 5-year survival rate was 53%, comparable to world wide and Japanese data. Thus, the conclusion is that this protocol was feasible in FNCA countries based on the favorable outcome. The follow-up rate of 73% should be improved for accuracy of the clinical study. The effort of decreasing number of lost cases was specially emphasized for future studies. A draft manuscript of CERVIX-I, which was planned to be submitted for the International Journal of Radiation Oncology, Biology & Physics, was distributed and discussed. | | | | | | Session2:
Accelerated Hyperfractionation Radiotherapy (CERVIX-II) | | | 4) | The follow-up data of CERVIX-II study as of December 2003 on 103 patients was presented. The overall 3-year survival rate was 83% for the whole group. Acute and late morbidity was thought to be acceptable. Questions were raised on cases excluded from the analysis, and the exclusion criteria were discussed. The Data Center was asked to review the submitted data. Institutes with lower follow up rate were reminded to improve it. The updated follow up and reviewed data will be presented at the next meeting. | | | | | Session3:
Chemoradiotherapy for Uterine Cervix Cancer | | | 5) | The Phase I study of concurrent chemoradiotherapy (CCRT) of uterine cervix cancer was completed. Summarized data of 30 patients showed that there were no Gr. IV hematological and non-hematological toxicities. Only 1 patient had non-hematological Gr. III Dose Limiting Toxicity. The regimen of weekly Cisplatin (CDDP) at 40 mg/m2 was acceptable and will be used in the next phase. | | | 6) | A proposal of the Phase II Protocol of CCRT for Advanced Uterine Cervix Cancer was distributed, discussed, and agreed upon. The main discussions were on histology, stage and number of chemotherapy cycles. A hundred patients are to be enrolled with a minimum of 12 per country. The protocol was adopted as CERVIX-III. | | | | | | Session4:
Pilot study of Chemoradiotherapy for Nasopharyngeal Cancer | | | 7) | The results of major randomized studies and a meta-analysis were presented and reviewed. The addition of chemotherapy to radiation appears to improve outcomes in terms of Disease Free Survival (DFS) and Overall Survival, compared with RT alone. | | | 8) | The results of the pilot study were presented and summarized. No patients developed Gr. IV toxicities. The regimen of weekly CDDP 30mg/m2 appears safe but the safety of weekly CDDP 40mg/m2 needs to be confirmed. | | | 9) | A protocol for a Phase I/II study was presented and discussed. Intensity Modulated Radiation Therapy (IMRT) and/or brachytherapy will not be allowed in the protocol. Dose levels for Phase I and adjuvant chemotherapy were discussed. The Phase I study will continue for another year, with the possibility of a Phase II study later. Thailand was requested to try a feasibility study using concurrent +adjuvant regimen. A separate workshop on radiation therapy techniques and grading of radiation reaction was proposed in order to standardize both these aspects among participants as an essential basis prior to the Phase II trial. | | | 10) | The use of COX-II inhibitors, which have a radiosensitizing activity on tumour tissue and radio-protective effect on normal tissue, was explained and discussed. A randomized phase II study using a drug, meloxicam, was proposed. | | | | | | Session5:
QA/QC of Radiation Dosimetry | | | 11) | The results of fieldwork for physical QA/QC of brachytherapy were presented with description of measurement technique. The results of visits to 3 countries, Thailand, the Philippines and Vietnam, were considered acceptable. This field work was requested to be continued in the remaining countries, namely China, Indonesia, Japan, Korea and Malaysia. The meeting also suggested expanding the QA/QC activity to external beam therapy involving medical physicists of Member States. | | | | | | Session 6:
Future plans and other relevant activities | | | 12) | Future plans were discussed and approved. | | | 13) | The details of a new randomized phase II protocol for cervical and nasopharyngeal cancer using meloxicam was presented. Most of the participants expressed willingness to participate in the proposed trial with pharmaceutical grants. Research grants from pharmaceutical companies could be incorporated for future trials but the feasibility of including such trials as a part of the FNCA activity needs to be discussed further. | | | 14) | The meeting considered Thailand, Korea or the Philippines as the possible venue for the next workshop, in this order of priority. | | | | | | Technical tour | | | 15) | The participants visited Department of Radiotherapy, Suzhou No.1 Hospital and Shanghai Zhong Shan Cancer Centre, Fudan University, as a Technical Tour. | | | | | | Open Lecture | | | 16) | Day 4 was spent for the Open Lecture held at the Shanghai Zhong Shan Cancer Centre, Fudan University, Shanghai City, China, as a part of the workshop. Local participants to the Lecture include medical doctors, researchers and students. The Seminar was started by remarks given by Dr. H. Tsujii, NIRS. Nine lectures were given by FNCA participants and two local Chinese doctors.
(See attachment program) At the end of the Open Lecture, Dr. Zhang Xin, China, gave his Closing Remarks. | | | | | | Session 7:
Drafting the Workshop Minutes | | | 17) | The draft minutes were discussed, amended and adopted. | | | | | | Closing ceremony | | | 18) | Participants expressed appreciation to MEXT, Soochow University, local staff organizing the meeting, JAIF and Fudan University. The participants also expressed their gratitude for the continuing support from the Government of Japan for this project. Closing Remarks were given by Dr. H. Tsujii, who expressed his appreciation to the host institutes and participants. | | | | | Attachment | | -Program of the Workshop | | -Participant List | | -Future plan | |
|
|
Program of
FNCA 2003 Workshop
on Radiation Oncology
Monday, December 15 to Thursday, December 18
Suzhou(Soochow)/Shanghai, China
|
| | | Organized by |
: |
College of Nuclear Medicine, Soochow University
Ministry of Education, Culture, Sports, Science, and Technology (MEXT) |
| In cooperation with |
: |
Fudan University
Japan Atomic Industrial Forum |
| Date |
: |
December 15-18, 2003 |
| Venue |
: |
ASTER HOTEL in Suzhou City, China
Shanhai Zhong Shan Cancer Center in Shanghai City, China |
| | | | -Sunday, December 14- |
| |  | | Arrive at Shanghai Airport, Move to ASTER HOTEL in Suzhou City |
| | | | | -Monday, December 15- |
| | | | 08:00-8:30 |
Registration |
| <Opening Session> | Chair: Cao Jianping, Professor, Radiation Genetic & Biology Division,
College of Nuclear Medicine, Soochow University | | 08:30-09:00 | Welcome Remarks:
| Jianyi Ge, Director of Soochow University | Welcome Remarks:
| Tong Jian, Professor, Director of Radiation Medicine and Publical Health School, Soochow University | | Remarks: | Tokuko Kuroyanagi, Official, Atomic Energy
Division, Research and Development Bureau,
MEXT | | Welcome Remarks: | Li Xiang, Deputy Director, Division of
Nuclear Affiars and International Organizations, Department of International Cooperation, China Atomic Energy Authority(CAEA) | | Remarks: | Hirohiko Tsujii, Supervisory Director,
Research Center for Charged Particle Therapy National Institute of Radiological Sciences (NIRS) | | Adoption of the Agenda | | Election of Co-Chairs | | * It is requested that one of Co-Chairs play the role of rapporteur. | | Group Photograph | | | < Session1> | | Follow-Up Status of Patients Treated with the Standardized Protocol of Radiation Therapy for Uterine Cervix Cancer (CERVIX-I)
Co-Chairs: Supriana, N., Indonesia
Nakano, T., Japan |
| 09:00-09:40 | 1) | Presentation of the follow-up data | | Kato, S., NIRS, Japan | | | 09:40-10:00 | 2) | Preparation for submitting the manuscript to a journal | | Nakano, T., Japan | | | 10:00-10:30 | Coffee Break | | | < Session2> | | Accelerated Hyperfractionation Radiotherapy for Uterine Cervix Cancer (CERVIX-II)
Co-Chairs: TO, A., D., Viet Nam
Suto, H., Japan |
| 10:30-11:10 | 1) | Presentation of the follow-up data | | Ohno, T., NIRS, Japan | | | 11:10-12:00 | 2) | Discussion | | | 12:00-13:00 | Lunch time | | | < Session3> | Chemoradiotherapy for Uterine Cervix Cancer (CERVIX-III)
Co-Chairs: Calaguas, M.J.C., the Philippines
Janjira Petuksiri, Thailand
Kato, S., Japan |
| 13:00-14:30 | 1) | Presentation on the Results of the Phase I Study of Concurrent Chemoradiotherapy for Uterine Cervix Cancer (CERVIX-III) | | Kato, S., Japan | | Reyes, R.H.D.L., the Philippines | | Fuad B Ismail, Malaysia | | Zhou Beibei, China | | 2) | Summary of the cooperative clinical study | | Kato S., Japan | | | 14:30-16:00 | Proposal of the Phase II Protocol of Chemoradiotherapy for Advanced Uterine Cervix Cancer (CERVIX-IV) | | Discussion | | | 16:00-16:30 | Coffee break | | | 16:30-18:00 | Adoption of the Phase II Protocol | | | 18:30- | Welcome Party hosted by Radiation Medicine and Publical Health School, Soochow University | | | | | | -Tuesday, December 16- |
| | | < Session4> | Pilot study of Chemoradiotherapy for Nasopharyngeal Cancer
Co-Chairs: Fuad, B Ismail, Malaysia
Inoue T., Japan
R. Susworo, Indonesia |
| 08:30-08:45 | Overview of treatment options and clinical trials of nasophatygeal cancer | | Kato S., Japan | | | 08:45-09:20 | Presentation on the results of the pilot study | | | Janjira Petuksiri, Thailand | | Miriam J Calaguas, the Philippines | | Fuad B Ismail, Malaysia | | Zhou Juying, China |
| Summary of the pilot study | | | Ohno, T., Japan | | | 09:20-10:00 | Proposal of the Phase II Protocol of Chemoradiotherapy for Nasopharyngeal Cancer | | Ohno, T., Japan | | | 10:00-10:30 | Coffee Break | | | 10:30-11:30 | Discussion | | | 11:00-12:00 | Adoption of the protocol | | | 12:00-13:00 | Lunch time | | | 13:00-14:30 | Presentation on the Cox-II inhibitor and General Discussion | | Kobayashi K., Japan | | | < Session5> | QA/QC of Radiation Dosemetry
Co-Chairs: Chul-Koo CHO, Korea
Tatsuzaki, H., Japan |
| 14:30-15:00 | 1)
| Report of the Fieldwork | | 2) | QA/QC Manuals | | Nakamura, Y., Japan | | | 15:00-15:30 | 3)
| Schedule of the next Fieldwork | | | 15:30-16:00 | Coffee break | | | < Session6> | Future plan, Other activities
Co-Chairs: Tsujii, H., Japan
Cao Jianping, China |
| 16:00-18:00 | 1)
| Future plan | | 2) | Others | | 3) | Schedule of the next Workshop | | | 18:30 | Dinner time | | | | | | -Wednesday, December 17- |
| | | < Session7> | Drafting the Workshop Minutes
Co-Chairs: Tatsuzaki, H., Japan
Calaguas, M.J.C., the Philippines
Fuad, B.I., Malaysia |
| 08:30-9:30 | Discussion | | | 09:30-10:00 | Adoption of the Minutes | | | 10:00- |
Closing Remarks |
| Hirohiko Tsujii, Japan |
| | 10:30- | Technical Tour | | | 10:30 -12:00 | 1) | Department of Radiotherapy, Suzhou No.1 Hospital | | | 12:00- 13:00 | Lunch time, Suzhou | | | 13:00- 15:00 | Move to Shanghai City | | | 15:00- 17:00 | 2) | Shanghai Zhong Shan Cancer Centre, Fudan University, Shanghai city, China | | | 18:00- | Dinner time | | | | | | -Thursday, December 18- |
| | | <Open Lecture> | | Shanghai Zhong Shan Cancer Centre, Fudan University, Shanghai city, China |
| 09:00-09:15 | Registration | | <Opening Ceremony> | | 09:15-09:30 | Chair: | Cao Jianping, Professor, Radiation Genetic & Biology
Division, College of Nuclear Medicine,
Soochow University | | Opening Remarks: | Hirohiko Tsujii, Supervisory Director,
Research Center for Charged Particle Therapy National Institute of Radiological Sciences (NIRS) | | | <Open Lecture> | | 09:30-13:00 |
1) |
Introduction of Depatment of Radiation Oncology Zhongshan Hospital, Fudan University |
| ZhaoChong Zeng, China |
| 2) |
Tumor Traking System using Robotic Linear Accelerator |
| Inoue, T., Japan |
| 3) |
Achievement FNCA Project on Radiation Oncology |
| Kato, S., Japan |
| 4) |
Present status of radiation therapy in China |
| Wang Jian, China |
| 5) |
Role of CyberKnife for the treatment of Para-aortic LNs metastasis in the Uterine Cervix and Colorectal carcinomas |
| Cho, C.K., Korea |
| 6) |
Current status of carcinoma and radiation therapy in China |
| Zhou Juying, China |
| 7) |
Particle Beam Therapy HIMAC |
| Tsujii, H., Japan |
| 8) |
IMRT (Intensity Modulated Radiation Therapy) |
| Calaguas, M.J.C., the Philippines |
| 9) |
Recent status of radiation therapy for cervical cancer |
| Nakano, T., Japan |
| | <Closing Ceremony> | Chair
Cao Jianping, China |
| 13:00- |
Closing Remarks:
| Zhang Xin, Vice-Derector of Branth of Zhongshang Hospital | | Remarks: | Hirohiko Tsujii, Supervisory Director,
Research Center for Charged Particle Therapy National Institute of Radiological Sciences (NIRS) | | |
Participants of FNCA 2003 Workshop
of Radiation Oncology
|
| |
| China | | Name |
Title |
Organization |
| Prof. Cao Jianping |
Professor, Radiation Genetic & Biology |
College of Nuclear Medicine, Soochow University |
| | Dr. Zhou Beibei |
Head, Department of Gynecological |
The First Affiliated Hospital of Soochow University |
| | Dr. Zhou Juying |
Head, Department of Radiotherapy |
The First Affiliated Hospital of Soochow University |
| | | |
| Indonesia | | Name | Title |
Organization |
| Dr. Susworo | Medical Doctor |
Faculty of Medicine University of Indonesia Jakarta Indonesia |
| | Dr. Nana Supriana | Medical Doctor |
Faculty of Medicine University of Indonesia Jakarta Indonesia |
| | | |
| Japan | | Name |
Title |
Organization |
| Dr. Hirohiko Tsujii |
Director, Research Center for Charged Particle Therapy |
National Institute of Radiological Sciences |
| | Dr. Takehiro Inoue |
Asociate Professor |
Osaka University Graduate School of Medicine |
| | Prof. Takashi Nakano |
Professor |
Gunma University Graduate School of Medicine |
| | Dr. Kunihiko Kobayashi |
Head, Physician of Outpatient Clinic |
Saitama Cancer Center |
| | Dr. Shingo Kato |
Head, Research Center for Charged Particle Therapy |
National Institute of Radiological Sciences |
| | Dr. Hideo Tatsuzaki |
Head, International Co-operation Section |
National Institute of Radiological Sciences |
| | Dr. Tatsuya Ohno |
Senior Doctor, Research Center for Charged Particle Therapy |
National Institute of Radiological Sciences |
| | Dr. Sadayoshi Kobayashi |
M.D. & Ph.D |
National Institute of Radiological Sciences |
| | Dr. Hiroshi Tsunemoto |
M.D. & Ph.D |
National Institute of Radiological Sciences |
| | Dr. Hisao Suto |
Head, Department of Radiology |
Matsudo City Hospital |
| | Dr. Yuzuru Nakamura |
Consultant medical physicist, Department of Radiation Oncology |
Saitama Medical School |
| | Ms. Tokuko Kuroyanagi |
Offcial, Atomic Energy Division Research & Development Bureau |
MEXT |
| | Mr. Hideo Nakasugi |
General Manager, Asia Cooperation Center |
JAIF |
| | Mr. Tomoyuki Teranaka |
Project Manager, Asia Cooperation Center |
JAIF |
| | | | | Korea | | Name | Title | Organization | | Dr. Chul-Koo Cho | Director, Division of Medical Services | Korea Cancer Center Hospital | | | | |
| Malaysia | | Name | Title |
Organization |
| Dr. Fuad Ismail | Doctor, Department of Radiotherapy & Oncology |
Hospital University Kebangsaan Malaysia |
| | | |
| The_Phillippines | | Name | Title |
Organization |
| Dr. Miriam Joy C. Calaguas | Doctor, Department of Radiation Oncology |
St. Luke's Medical Center |
| | Dr. Rey H. de los Reyes | Chairman, Department of Obsterrics and Gynecology |
Dr. Jose Reyes Memorial Medical Center |
| | | | | Thailand | | Name | Title |
Organization |
| Dr. Nan Suntornpong | Assistant Professor, Fuclty of Medicine, Mahidol University | Radiology Department, Radiation Therapy, Siriraj Hospital | | | Dr. Janjira Petsuksiri | Radiation Oncologist, Fuclty of Medicine, Mahidol University | Radiology Department, Radiation Therapy, Siriraj Hospital | | | | |
| Vietnam | | Name | Title |
Organization |
| Dr. To Anh Dung | Vice-Head, Breast and Gynecology Radiotherapy Department |
National Cancer Institute |
| | Dr. Le Phuc Thinh | Head, Radiation Therapy Department |
Ho Chi Minh city Cancer Center |
| | | |
|
|
